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That same year she appeared in Westbeth Playwrights Feminist Collective's production of Up – An Uppity Revue, along with her future husband, Danny De Vito.
One of her first notable parts was a recurring role on the television show Taxi as Zena, the sweet girlfriend of Louie De Palma (played by De Vito).
She was also nominated for a Golden Globe for Best Supporting Actress six times, more than anyone else in that category.
In 2011, CBS named Carla Tortelli as one of the greatest TV characters of all time.
In 1992, she starred in the made-for-TV-movie, To Grandmother's House We Go opposite Ashley Olsen and Mary-Kate Olsen, playing the wife of Jerry Van Dyke's character; the couple kidnapped the Olsen Twins' characters, hoping to cash in on ransom before Christmas.
Other TV films in which she starred included the dramas A Place to Be Loved and In Spite of Love.
Perelman is annually one of the world's largest philanthropic donors.
Since 2014, she has starred in a recurring role on The Mindy Project as Danny's mother, Annette Castellano.In 1994, Perlman voiced 9-Eye in The Timekeeper, a Circle-Vision show at the Magic Kingdom in Tomorrowland.She later starred in the 1996 sitcom Pearl as the title character and was featured on the 2001 TV drama Kate Brasher.Perlman's motion picture roles included There Goes The Neighborhood (1992), Canadian Bacon (1995), Carpool (1996), Sunset Park (1996), and Matilda (1996).She had a cameo in the film 10 Items Or Less (2006), and also starred in the 2007 independent film Love Comes Lately.