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Overall, the high regenerative capacity and key phylogenetic position of cnidarians provide a unique opportunity to study the basic mechanism underlying animal wound repair.

This type of study is of great interest in comparison to other highly regenerative animals (to see similarities) and in comparison to animals that lack the capacity to regenerate (to see differences).

These structures were not repaired at six hours and may need proliferation to regrow [ wound healing.

(A) Timeline of morphological events during the first six hours after injury.

Filamentous actin, a core component of the extracellular matrix and muscle fibers, was labeled with Phallacidin-FL (false-colored black).

Puncture wounds span both sides of the animal creating two similar wounds.

The mitogen-activated protein kinase (MAPK) signaling pathway is present in all eukaryotic genomes and functions in a wide range of cellular processes including immune system regulation, proliferation, apoptosis, cell signaling and movement.

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